Human Mothers Against Decapentaplegic Homolog 6, SMAD6 ELI

Acts as a mediator of TGF-beta and BMP antiflammatory activity.

Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes.

May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding.

Binds to regulatory elements in target promoter regions.