Human Mucin-1, MUC1 ELI

The alpha subunit has cell adhesive properties.

Can act both as an adhesion and an anti-adhesion protein.

May provide a protective layer on epithelial cells against bacterial and enzyme attack.

The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions.

Modulates signaling in ERK, SRC and NF-kappa-B pathways.

In activated T-cells, influences directly or indirectly the Ras/MAPK pathway.

Promotes tumor progression.

Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response.

Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.