Human Mucolipin 2, MCOLN2 ELI
3,140.00 ₪
Nonselective cation Channel probably playing a role in the regulation of membrane trafficking events.
Acts as Ca(2+)-permeable cation Channel with inwardly rectifying activity (PubMed: 19940139, PubMed: 19885840).
May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed: 17662026).
May play a role in immune processes.
In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity).
In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity).
Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed: 19885840).
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