Human Multidrug and Toxin Extrusion Protein 1, SLC47A1 ELI

Solute transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, acyclovir, ganciclovir and also the zwitterionic cephalosporin, cephalexin and cephradin.

Seems to also play a role in the uptake of oxaliplatin (a new platinum anticancer agent).

Able to transport paraquat (PQ or N,N-dimethyl-4-4'-bipiridinium); a widely used herbicid.

Responsible for the secretion of cationic drugs across the brush border membranes.