Human Multidrug Resistance-associated Protein 1, ABCC1 ELI
3,140.00 ₪
Mediates export of organic anions and drugs from the cytoplasm (PubMed: 7961706, PubMed: 16230346, PubMed: 9281595, PubMed: 10064732, PubMed: 11114332).
Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics (PubMed: 7961706, PubMed: 16230346, PubMed: 9281595, PubMed: 10064732, PubMed: 11114332).
Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export (PubMed: 9281595).
Hydrolyzes ATP with low efficiency (PubMed: 16230346).
Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation (PubMed: 17050692).
Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells (By similarity).
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