Human Muscarinic Acetylcholine Receptor M2, M-ACHR M2 ELI

The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium Channels through the action of G proteins.

Primary transducing effect is adenylate cyclase inhibition.

Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.