Human Muscleblind-like protein 3,MBNL3 ELI

Mediates pre-mRNA alternative splicing regulation.

Acts either as activator or repressor of splicing on specific pre-mRNA targets.

Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle.

Antagonizes the alternative splicing activity pattern of CELF proteins.

May play a role in myotonic dystrophy pathophysiology (DM).

Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.

{ECO:0000269|PubMed:12297108, ECO:0000269|PubMed:15257297}.