Human Myc Box-dependent-interacting Protein 1, BIN1 ELI
3,140.00 ₪
Is a key player in the control of plasma membrane curvature, membrane shaping and membrane remodeling.
Required in muscle cells for the formation of T-tubules, tubular invaginations of the plasma membrane that function in depolarization-contraction coupling (PubMed: 2$475.00|$350.005653).
Is a negative regulator of endocytosis (By similarity).
Is also involved in the regulation of intracellular vesicles sorting, modulation of BACE1 trafficking and the control of amyloid-beta production (PubMed: 27179792).
In neuronal circuits, endocytosis regulation may influence the internalization of PHF-tau aggregates (By similarity).
May be involved in the regulation of MYC activity and the control cell proliferation (PubMed: 8782822).
Has actin bundling activity and stabilizes actin filaments against depolymerization in vitro (PubMed: 28893863).
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