Human Nacht, Lrr and Pyd Domains-containing Pprotein 2, NLRP2 ELI

Suppresses TNF- and CD40-induced NFKB1 activity at the level of the IKK complex, by inhibiting NFKBIA degradation induced by TNF.

When associated with PYCARD, activates CASP1, leading to the secretion of mature proinflammatory cytokine IL1B.

May be a component of the inflammasome, a protein complex which also includes PYCARD, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.