Human NAD-dependent protein deacylase sirtuin-5, mitochondrial,SIRT5 ELI

NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693, PubMed:29180469).

Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693).

Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062).

Activates SHMT2 by mediating its desuccinylation (PubMed:29180469).

Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity).

Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.

Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

{ECO:0000250|UniProtKB:Q8K2C6, ECO:0000269|PubMed:18680753, ECO:0000269|PubMed:21908771, ECO:0000269|PubMed:22076378, ECO:0000269|PubMed:24140062, ECO:0000269|PubMed:24703693, ECO:0000269|PubMed:29180469}.