Human Nadphoxidase 4, NOX4 ELI
3,140.00 ₪
Constitutive NADPH oxidase which generates superoxide intracellularly upon formation of a complex with CYBA/p22phox.
Regulates signaling cascades probably through phosphatases inhibition.
May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium Channel and HIF1A activity.
May regulate insulin signaling cascade.
May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB.
May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation.
Isoform 3 is not functional.
Isoform 5 and isoform 6 display reduced activity.
[Isoform 4]: Involved in redox signaling in vascular cells.
Constitutively and NADPH-dependently generates reactive oxygen species (ROS).
Modulates the nuclear activation of ERK1/2 and the ELK1 transcription factor, and is capable of inducing nuclear DNA damage.
Displays an increased activity relative to isoform 1.
Quantity