Human Netrin Receptor Dcc, DCC ELI

Receptor for netrin required for axon guidance.

Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding.

Its association with UNC5 proteins may trigger signaling for axon repulsion.

It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand.

Implicated as a tumor suppressor gene.