Human Netrin Receptor Unc5D, UNC5D ELI

Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity).

Plays a role in cell-cell adhesion and cell guidance.

Receptor for netrin involved in cell migration.

Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity).

May play a role in apoptosis in response to DNA damage (PubMed: 24691657).

It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed: 24519068).

Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity).