Human Neural Cell Adhesion Molecule L1-like Protein, CHL1 ELI

Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity.

Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death.

Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses.

May play a role in regulating cell migration in nerve regeneration and cortical development.

Potentiates integrin-dependent cell migration towards extracellular matrix proteins.

Recruits ANK3 to the plasma membrane (By similarity).