Human Neural Cell Adhesion Molecule L1-Like Protein, CHL1 Primacu™ ELI

Neural cell adhesion molecule L1-like protein, also known as close homolog of L1 (CHL1) is the prototypic member of the CTF / NF-1 family of transcription factors that serve as a novel calcium signaling pathway-responsive transcription factor and is considered as a member of the largest ctf complementation group, consisting of 30 of 126 ctf mutants isolated.

CHL1 is a cell adhesion molecule highly related to L1.

It contains structure plan of six extracellular C2-type immunoglobulin (Ig) domains followed by five fibronectin type Ⅲ domains linked by a single membrane-spanning region to a short cytoplasmic domain.

The extracellular portion of CHL1 is higyly glycosylated and involved in hemophilic disease.