Human neuregulin-4,NRG4 ELI

Low affinity ligand for the ERBB4 tyrosine kinase receptor.

Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors.

Does not bind to the ERBB1, ERBB2 and ERBB3 receptors (By similarity).

{ECO:0000250}.