Human Neurogenic Locus Notch Homolog Protein 2, NOTCH2 ELI

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination.

Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed: 21378985, PubMed: 21378989).

Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).

Involved in bone remodeling and homeostasis.

In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed: 29149593).

Positively regulates self-renewal of liver cancer cells (PubMed: 25985737).