Human Neurogenic Locus Notch Homolog Protein 3, NOTCH3 ELI

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).