Human Neurogenic Locus Notch Homolog Protein 4, NOTCH4 ELI

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination.

Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus.

Affects the implementation of differentiation, proliferation and apoptotic programs.

May regulate branching morphogenesis in the developing vascular system (By similarity).