Human Neurotrophic tyrosine kinase receptor type 2, NTRK2 Primacu™ ELI

TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity.

TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family.

TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways.

There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor.

Each family member binds different neurotrophins with varying affinities.

TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons.

Other neurotrophins include nerve growth factor(NGF), neurotrophin-3 and neurotrophin-4.

TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway.

Signaling through this kinase leads to cell differentiation.

Mutations in TrkB/NTRK have been associated with obesity and mood disorders.

Cancer Immunotherapy Immune Checkpoint Immunotherapy Targeted Therapy