Human Nischarin, NISCH ELI

Acts either as the functional imidazoline-1 receptor (I1R) candidate or as a membrane-associated mediator of the I1R signaling.

Binds numerous imidazoline ligands that induces initiation of cell-signaling cascades triggering to cell survival, growth and migration.

Its activation by the agonist rilmenidine induces an increase in phosphorylation of mitogen-activated protein kinases MAPK1 and MAPK3 in rostral ventrolateral medulla (RVLM) neurons that exhibited rilmenidine-evoked hypotension (By similarity).

Blocking its activation with efaroxan abolished rilmenidine-induced mitogen-activated protein kinase phosphorylation in RVLM neurons (By similarity).

Acts as a modulator of Rac-regulated signal transduction pathways (By similarity).

Suppresses Rac1-stimulated cell migration by interacting with PAK1 and inhibiting its kinase activity (By similarity).

Also blocks Pak-independent Rac signaling by interacting with RAC1 and inhibiting Rac1-stimulated NF-kB response element and cyclin D1 promoter activation (By similarity).

Inhibits also LIMK1 kinase activity by reducing LIMK1 'Tyr-508' phosphorylation (By similarity).

Inhibits Rac-induced cell migration and invasion in breast and colon epithelial cells (By similarity).

Inhibits lamellipodia formation, when overexpressed (By similarity).

Plays a role in protection against apoptosis.

Involved in association with IRS4 in the enhancement of insulin activation of MAPK1 and MAPK3.

When overexpressed, induces a redistribution of cell surface ITGA5 integrin to intracellular endosomal structures.