Human Nkg2-D Type 2 Integral Membrane Protein, KLRK1 ELI

Functions as an activating and costimulatory receptor involved in immunosurveillance upon binding to various cellular stress-inducible ligands displayed at the surface of autologous tumor cells and virus-infected cells.

Provides both stimulatory and costimulatory innate immune responses on activated killer (NK) cells, leading to cytotoxic activity.

Acts as a costimulatory receptor for T-cell receptor (TCR) in CD8(+) T-cell-mediated adaptive immune responses by amplifying T-cell activation.

Stimulates perforin-mediated elimination of ligand-expressing tumor cells.

Signaling involves calcium influx, culminating in the expression of TNF-alpha.

Participates in NK cell-mediated bone marrow graft rejection.

May play a regulatory role in differentiation and survival of NK cells.

Binds to ligands belonging to various subfamilies of MHC class I-related glycoproteins including MICA, MICB, RAET1E, RAET1G, RAET1L/ULBP6, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4.