Human Nuclear Factor of Activated T-cells, Cytoplasmic 1, NFATC1 ELI

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription.

Also controls gene expression in embryonic cardiac cells.

Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed: 10358178).

Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity).