Human Nuclear Inhibitor of Protein Phosphatase 1, PPP1R8 ELI

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1).

It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates.

May also be involved in pre-mRNA splicing.

Binds DNA and might act as a transcriptional repressor.

Seems to be required for cell proliferation.

Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions.

It generates 5'-phosphate termini at the site of cleavage.

This isoform does not inhibit PP-1.

May be implicated in mRNA splicing.