Human Nucleolin, NCL ELI

Nucleolin is the major nucleolar protein of growing eukaryotic cells.

It is found associated with intranucleolar chromatin and pre-ribosomal particles.

It induces chromatin decondensation by binding to histone H1.

It is thought to play a role in pre-rRNA transcription and ribosome assembly.

May play a role in the process of transcriptional elongation.

Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.