Human osteoclast differentiation factor,ODF ELI
3,140.00 ₪
Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK.
Osteoclast differentiation and activation factor.
Augments the ability of dendritic cells to stimulate naive T-cell proliferation.
May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response.
May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871).
Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts.
During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
{ECO:0000250|UniProtKB:O35235, ECO:0000269|PubMed:22664871}.
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