Human Oxysterol-binding Protein-related Protein 3, OSBPL3 ELI
3,140.00 ₪
Phosphoinositide-binding protein which associates with both cell and endoplasmic reticulum (ER) membranes (PubMed: 16143324).
Can bind to the ER membrane protein VAPA and recruit VAPA to plasma membrane sites, thus linking these intracellular compartments (PubMed: 25447204).
The ORP3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface (PubMed: 18270267, PubMed: 25447204).
With VAPA, may regulate ER morphology (PubMed: 16143324).
Has a role in regulation of the actin cytoskeleton, cell polarity and cell adhesion (PubMed: 18270267).
Binds to phosphoinositides with preference for PI(3,4)P2 and PI(3,4,5)P3 (PubMed: 16143324).
Also binds 25-hydroxycholesterol and cholesterol (PubMed: 17428193).
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