Human P2X Purinoceptor 7, P2RX7 ELI

Receptor for ATP that acts as a ligand-gated ion channel.

Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules.

Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells.

In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).