Human Pachytene Checkpoint Protein 2 Homolog, TRIP13 ELI

Plays a key role in chromosome recombination and chromosome structure development during meiosis.

Required at early steps in meiotic recombination that leads to non-crossovers pathways.

Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways.

Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation.

In males, required for efficient synapsis of the sex chromosomes and for sex body formation.

Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes.

Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Plays a role in mitotic spindle assembly checkpoint (SAC) activation (PubMed: 28553959).