Human Pancreas Duodenum Homeobox Protein 1, PDX1 ELI

Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription.

Particularly involved in glucose-dependent regulation of insulin gene transcription.

As part of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element.

Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'.

During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation.

At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell.