Human Peptidyl-prolyl Cis-Trans Isomerase D, CYCLOPHILIN-40 ELI
3,140.00 ₪
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes.
Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control.
May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes.
May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus.
May regulate MYB by inhibiting its DNA-binding activity.
Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity.
Involved in regulation of UV radiation-induced apoptosis.
Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release.
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