Human Peptidyl-prolyl cis-trans isomerase FKBP5,FKBP5 ELI

Immunophilin protein with PPIase and co-chaperone activities (PubMed:11350175).

Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90).

Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded (PubMed:12538866).

Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1 (PubMed:28147277).

{ECO:0000269|PubMed:11350175, ECO:0000269|PubMed:12538866, ECO:0000269|PubMed:28147277}.