Human PH Domain Leucine Rich Repeat Protein Phosphatase 1,PHLPP1 ELI

Protein phosphatase involved in regulation of Akt and PKC signaling.

Mediates dephosphorylation in the C-terminal domain hydrophobic motif of members of the AGC Ser/Thr protein kinase family; specifically acts on 'Ser-473' of AKT2 and AKT3, 'Ser-660' of PRKCB and 'Ser-657' of PRKCA (PubMed:15808505, PubMed:17386267, PubMed:18162466).

Isoform 2 seems to have a major role in regulating Akt signaling in hippocampal neurons (By similarity).

Akt regulates the balance between cell survival and apoptosis through a cascade that primarily alters the function of transcription factors that regulate pro- and antiapoptotic genes.

Dephosphorylation of 'Ser-473' of Akt triggers apoptosis and suppression of tumor growth.

Dephosphorylation of PRKCA and PRKCB leads to their destabilization and degradation (PubMed:18162466).

Dephosphorylates STK4 on 'Thr-387' leading to STK4 activation and apoptosis (PubMed:20513427).

Dephosphorylates RPS6KB1 and is involved in regulation of cap-dependent translation (PubMed:21986499).

Inhibits cancer cell proliferation and may act as a tumor suppressor (PubMed:19079341).

Dephosphorylates RAF1 inhibiting its kinase activity (PubMed:24530606).

May act as a negative regulator of K-Ras signaling in membrane rafts (By similarity).

Involved in the hippocampus-dependent long-term memory formation (By similarity).

Involved in circadian control by regulating the consolidation of circadian periodicity after resetting (By similarity).

Involved in development and function of regulatory T-cells (By similarity).

{ECO:0000250|UniProtKB:Q8CHE4, ECO:0000250|UniProtKB:Q9WTR8, ECO:0000269|PubMed:15808505, ECO:0000269|PubMed:17386267, ECO:0000269|PubMed:18162466, ECO:0000269|PubMed:19079341, ECO:0000269|PubMed:21986499, ECO:0000269|PubMed:24530606}.