Human Phosphatidylinositol 3,4, 5-Trisphosphate-dependent Rac Exchanger 1 Protei

Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP.

Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein.

May function downstream of heterotrimeric G proteins in neutrophils.