Human Phosphatidylinositol 3,4, 5-Trisphosphate-dependent Rac Exchanger 2 Protei

Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP.

Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein.

Mediates the activation of RAC1 in a PI3K-dependent manner.

May be an important mediator of Rac signaling, acting directly downstream of both G protein-coupled receptors and phosphoinositide 3-kinase.