Human Phosphodiesterase 9A,PDE9A ELI

Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.

Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP (PubMed:9624146, PubMed:18757755, PubMed:21483814).

Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle.

Does not regulate nitric oxide-dependent cGMP in heart (PubMed:25799991).

Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable).

In brain, involved in cognitive function, such as learning and long-term memory (By similarity).

{ECO:0000250|UniProtKB:Q8QZV1, ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814, ECO:0000269|PubMed:25799991, ECO:0000269|PubMed:9624146, ECO:0000305}.