Human Phosphoinositide 3-kinase Adapter Protein 1, PIK3AP1 ELI

Signaling adapter that contributes to B-cell development by linking B-cell receptor (BCR) signaling to the phosphoinositide 3-kinase (PI3K)-Akt signaling pathway.

Has a complementary role to the BCR coreceptor CD19, coupling BCR and PI3K activation by providing a docking site for the PI3K subunit PIK3R1.

Alternatively, links Toll-like receptor (TLR) signaling to PI3K activation, a process preventing excessive inflammatory cytokine production.

Also involved in the activation of PI3K in natural killer cells.

May be involved in the survival of mature B-cells via activation of REL.