Human Pituitary Adenylate Cyclase-activating Polypeptide, ADCYAP1 ELI

Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells.

Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.

In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion (By similarity). Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells (By similarity).