Human Plasminogen Activator Inhibitor 1, PAI-1 ELI

Serine protease inhibitor.

Inhibits TMPRSS7 (PubMed: 15853774).

Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU).

As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots (PubMed: 8481516, PubMed: 9207454, PubMed: 17912461).

As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading (PubMed: 9175705).

Acts as a regulator of cell migration, independently of its role as protease inhibitor (PubMed: 15001579, PubMed: 9168821).

It is required for stimulation of keratinocyte migration during cutaneous injury repair (PubMed: 18386027).

It is involved in cellular and replicative senescence (PubMed: 16862142).

Plays a role in alveolar type 2 cells senescence in the lung (By similarity).

Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis (PubMed: 25808697, PubMed: 27046084).