Human Plexin A4, PLXNA4 ELI

Coreceptor for SEMA3A.

Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.

Plays a role in axon guidance in the developing nervous system.

Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.

The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).