Human Plexin B3, PLXNB3 ELI

Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration.

Stimulates neurite outgrowth and mediates Ca2+/Mg2+-dependent cell aggregation.

In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1.