Human Polycystin-1, PKD1 ELI

Component of a heteromeric calcium-permeable ion Channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B (PubMed: 27214281).

Both PKD1 and PKD2 are required for Channel activity (PubMed: 27214281).

Involved in renal tubulogenesis (PubMed: 12482949).

Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium (By similarity).

Acts as a regulator of cilium length, together with PKD2 (By similarity).

The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling (By similarity).

The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity).

May be an ion-Channel regulator.

Involved in adhesive protein-protein and protein-carbohydrate interactions.