Human Polypeptide N-acetylgalactosaminyltransferase 11, GALNT11 ELI

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1.

O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1.

Not involved in glycosylation of erythropoietin (EPO).