Human Polypeptide N-Acetylgalactosaminyltransferase 2, GALNT2 ELI

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor.

Has a broad spectrum of substrates for Peptides such as EA2, Muc5AC, Muc1a, Muc1b.

Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.

Involved in O-linked glycosylation of APOC-III, ANGPTL3 and PLTP.

It participates to the regulation of HDL-C metabolism (PubMed: 27508872, PubMed: 32293671).