Human Potassium Voltage-gated Channel Subfamily E Member 1, KCNE1 ELI

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium Channel complex of pore-forming alpha subunits.

Modulates the gating kinetics and enhances stability of the Channel complex.

Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium Channel KCNB1 (PubMed: 19219384).

Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) Channel.

The outward current reaches its steady state only after 50 seconds.

Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).