Human Presenilin 2, PS-2 ELI
3,140.00 ₪
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein).
Requires the other members of the gamma-secretase complex to have a protease activity.
May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane.
May function in the cytoplasmic partitioning of proteins.
The holoprotein functions as a calcium-leak Channel that allows the passive movement of calcium from endoplasmic reticulum to cytosol and is involved in calcium homeostasis (PubMed: 16959576).
Is a regulator of mitochondrion-endoplasmic reticulum membrane tethering and modulates calcium ions shuttling between ER and mitochondria (PubMed: 21285369).
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