Human Pro-nerve Growth Factor, PRONGF ELI

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed: 14976160, PubMed: 20978020).

Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed: 20978020) (Probable).

The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse.

In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity).

Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (PubMed: 20164177).

Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer.

The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).