Human Probable lysosomal cobalamin transporter,LMBRD1 ELI
3,140.00 ₪
Lysosomal membrane chaperone required to export cobalamin (vitamin B12) from the lysosome to the cytosol, allowing its conversion to cofactors (PubMed:19136951).
Targets ABCD4 transporter from the endoplasmic reticulum to the lysosome (PubMed:27456980).
Then forms a complex with lysosomal ABCD4 and cytoplasmic MMACHC to transport cobalamin across the lysosomal membrane (PubMed:25535791).
Acts as an adapter protein which plays an important role in mediating and regulating the internalization of the insulin receptor (INSR) (By similarity).
Involved in clathrin-mediated endocytosis of INSR via its interaction with adapter protein complex 2 (By similarity).
Essential for the initiation of gastrulation and early formation of mesoderm structures during embryogenesis (By similarity).
{ECO:0000250|UniProtKB:Q8K0B2, ECO:0000269|PubMed:19136951, ECO:0000269|PubMed:27456980, ECO:0000303|PubMed:25535791}.; [Isoform 3]: (Microbial infection) May play a role in the assembly of hepatitis delta virus (HDV).
{ECO:0000269|PubMed:15956556}.
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