Human Programmed Cell Death Protein 4, PDCD4 ELI

Inhibits translation initiation and cap-dependent translation.

May excert its function by hindering the interaction between EIF4A1 and EIF4G.

Inhibits the helicase activity of EIF4A.

Modulates the activation of JUN kinase.

Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription.

May play a role in apoptosis.

Tumor suppressor.

Inhibits tumor promoter-induced neoplastic transformation.

Binds RNA (By similarity).