Human Proprotein Convertase Subtilisin/Kexin Type 5, PCSK5 ELI

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif.

Likely functions in the constitutive and regulated secretory pathways.

Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.